a, rat oligodendrocyte progenitor cells … agents that would induce differentiation of oligodendrocytes, which produce myelin basic protein (MBP). b, Benztropine enhanced axon myelination when added to a co-culture of oligodendrocyte progenitors and neurons. c, Benztropine promoted remyelination, … alleviated disease symptoms such as hind-leg and tail paralysis.
Multiple sclerosis: An old drug plays a new trick
Nature 502, 314–315 (17 October 2013)
Hartmut Wekerle & Edgar Meinl
A drug already used to treat Parkinson’s disease induces repair of the damage that occurs to the myelin sheath around nerve fibres during multiple sclerosis.
The finding offers new therapeutic avenues for this disease.