Developing Covid-19 Vaccines at Pandemic Speed


The Korea Times. March 18, 2020

Developing Covid-19 Vaccines at Pandemic Speed
NEJM. March 30, 2020
Nicole Lurie, M.D., M.S.P.H., et al.
https://www.nejm.org/doi/full/10.1056/NEJMp2005630

February 2020 ACIP Meeting
Centers for Disease Control and Prevention (CDC)

https://www.cdc.gov/vaccines/acip/meetings/index.html

PPE for microbial risk


2014
Centers for Disease Control and Prevention (CDC)

The Wall Street Journal, March 23, 2020
https://www.wsj.com/articles/u-s-strategic-stockpile-of-medical-supplies-is-outmatched-by-coronavirus-11584990542

The Wall Street Journal, March 23, 2020
https://www.wsj.com/articles/grocers-stopped-stockpiling-food-then-came-coronavirus-11584982605

How Doctors Stay Safe Battling Coronavirus
WSJ. February 19, 2020
https://www.wsj.com/video/how-doctors-stay-safe-battling-coronavirus/1EC32937-00FA-497E-ABB8-8A72B4FBED20.html

  • face shield
  • respirator of some sort
  • disposable coverall
  • gloves

Zoonotic spillover from mammals

Host and viral traits predict zoonotic spillover from mammals
Kevin J. Olival, et al.
Nature 546, 646–650 (29 June 2017)
https://www.nature.com/nature/journal/v546/n7660/full/nature22975.html
bats harbour a significantly higher proportion of zoonotic viruses than all other mammalian orders

Spillover Beasts: Which Animals Pose The Biggest Viral Risk?
June 21, 2017
http://www.npr.org/sections/goatsandsoda/2017/06/21/533702513/spillover-beasts-which-animals-pose-the-biggest-viral-risk

“We expect there are hundreds of thousands of mammalian viruses out there,” says Kevin Olival, a disease ecologist at EcoHealth Alliance, who led the study.

Zika virus’ risk to …: It’s deja vu

Lessons From Rubella Suggest Zika’s Impact Could Linger
March 23, 2016
http://www.npr.org/sections/health-shots/2016/03/22/470683695/lessons-from-rubella-suggest-zikas-impact-could-linger

As researchers try to figure out how much risk Zika virus poses to a fetus, Plotkin says it’s deja vu for folks who lived through that extensive rubella outbreak.

“It enabled the virologists, among them myself, to describe in detail what the virus was doing and to show beyond any doubt that the virus was infecting the fetus and causing the abnormalities,” says Plotkin.

rubella also pushed the federal government to create new programs for special education.

Metagenomics: crAssphage

A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes
Bas E. Dutilh, et al.
Nature Communications 5, Article number: 4498 Published  24 July 2014
http://www.nature.com/ncomms/2014/140724/ncomms5498/full/ncomms5498.html

Metagenomics, or sequencing of the genetic material from a complete microbial community, is a promising tool to discover novel microbes and viruses.
Viral metagenomes typically contain many unknown sequences.

Here we describe the discovery of a previously unidentified bacteriophage present in the majority of published human faecal metagenomes, which we refer to as crAssphage.
Its ~97 kbp genome is six times more abundant in publicly available metagenomes than all other known phages together; it comprises up to 90% and 22% of all reads in virus-like particle (VLP)-derived metagenomes and total community metagenomes, respectively; and it totals 1.68% of all human faecal metagenomic sequencing reads in the public databases.
The majority of crAssphage-encoded proteins match no known sequences in the database, which is why it was not detected before.
Using a new co-occurrence profiling approach, we predict a Bacteroides host for this phage, consistent with Bacteroides-related protein homologues and a unique carbohydrate-binding domain encoded in the phage genome.

Subject terms: Biological sciences
Bioinformatics
Virology

http://www.npr.org/tags/172709084/microbiome