Nov 26, 2013
Raw Food Not Enough to Feed Big Brains
By Ann Gibbons
Oct. 22, 2012
Jan 17, 2013
In Part 1, Marder introduces us to central pattern generators (CPGs), the circuits in the nervous system that control rhythmic movements such as walking or breathing. She goes on to explain that the stomatogastric nervous system from crustaceans is an excellent model system for studying CPGs, in part, because the connectivity of all the major neurons is known. Using the stomatogastic system, Marder and colleagues have asked how rhythmic circuits are generated and maintained over the life of the animal.
16:10 What generates the rhythm?
– Bursting pacemaker neurons (or oscillators) can drive rhythmic circuit
– Emerge from circuit interactions
+ reciprocal inhibition …
Sep 17, 2012
The Helix Center for Interdisciplinary Investigation of the New York Psychoanalytic Society & Institute
Metaphor: the brain is a kind of computer
computation: information processing
Is the diffusion of a chemical in the brain a computation?
It can be described by a computation.
<23:17 When we get a computation on our computer, if we type anything we get the same response every time.
If you get the same thing every time, you can’t learn. You can’t change. You can’t adapt.
Brain: You don’t get the same thing every time you do something
spontaneous pattern formation
1:15:00 primary sensory cortex: 7,000 synapses per cell
prefrontal cortex: 20,000 synapses per cell
able to generate its own activity in the absence of stimulus
there’s some background activity going on. It has to generate motor plans.
Neil Gaiman On Returning To ‘Sandman,’ Talking In His Sleep And The Power Of Comics
December 15, 2015
I think I love my dreaming process because one of the things that my dreaming process does is sort out stories for me.
I will go to sleep stuck on what happens next, I will wake up and somewhere these boys in the back room have been moving heavy furniture around, they’ve been digging, they’ve been painting, they’ve been plastering and they present me with the solution.
If that means I’m going to be a little bit chatty or a little bit weird in my sleep, I will go for it.
when you read everything, you wind up reading short stories or stories that just, you shouldn’t probably have read yet and the kinds of things that gave me nightmares.
The Graveyard Book
Normal brain ageing: models and mechanisms
Emil C Toescu
Published 29 December 2005.
Neurodegeneration: Cold shock protects the brain
Nature 518, 177–178 (12 February 2015)
Synaptic contacts are lost in hibernating mammals but reform when temperatures rise.
RBM3 is an RNA-binding cold-shock protein produced in the brain in response to cooling, but its function in synaptic plasticity is unknown. Giovanna Mallucci and colleagues show that impaired synapse regeneration in mouse neurodegenerative disease models is linked to a lack of induction of RMB3. Overexpression of RBM3 can restore the formation of synaptic contacts, while its loss-of-function triggers further defects in regeneration. These findings point to cold-shock proteins as components of endogenous repair processes and as possible therapeutic targets for neuroprotection in neurodegenerative disease.