Carfentanil

Deadly Opioid Overwhelms First Responders And Crime Labs in Ohio
September 25, 2016
http://www.npr.org/sections/health-shots/2016/09/25/495052633/deadly-opioid-overwhelms-first-responders-and-crime-labs-in-ohio

Heroin isn’t new in Cincinnati, but the recent surge in overdoses is being blamed on an even more potent drug called carfentanil. It’s 100 times stronger than fentanyl, a more common synthetic opioid that is itself much stronger than heroin. Carfentanil is used to sedate elephants. It can be dangerous to even touch it without gloves.

related:

http://www.npr.org/sections/health-shots/2016/09/02/492108992/an-even-deadlier-opioid-carfentanil-is-hitting-the-streets

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There is no safe level of lead exposure

High Lead Levels In Michigan Kids After City Switches Water Source
September 29, 2015
http://www.npr.org/2015/09/29/444497051/high-lead-levels-in-michigan-kids-after-city-switches-water-source

… He’d been tested before the city switched its water source. At that time, he had a level of 2 micrograms of lead per deciliter of blood. After the switch, his level was 6.5.

The Centers for Disease Control and Prevention says a level of 5 is considered “much higher” than that found in most children. It also says there is no safe level of lead exposure — and the effects, like lower IQ, are irreversible.

… researchers from Virginia Tech found that Flint River water is highly corrosive. That means when it comes into contact with lead from service lines, household pipes or solder, it eats away at the lead and sends it right to people’s faucets.
[In 1986 lead pipes were banned.]

City officials and state regulators say they’re now putting together a corrosion control plan to reduce lead exposure.

————————–
Doctor Who Discovered Children Had Elevated Lead Levels Talks About What’s Changed
September 17, 2017
http://www.npr.org/2017/09/17/551670868/doctor-who-discovered-children-had-elevated-lead-levels-talks-about-whats-change

Dr. Hanna-Attisha

we’re surrounding our kids with science, with evidence-based interventions that we know promote development and can mitigate the impact of lead.

universal preschool.
Every kid in Flint gets a book mailed to them every month from the ages of 0 to 5.

http://www.npr.org/2016/11/26/503416880/michigan-pediatrician-gives-update-on-childrens-health-one-year-after-flint-wate
early literacy and early intervention. And we have universal preschool
———————–

related:
http://www.npr.org/sections/health-shots/2015/10/18/449698380/calls-continue-for-epa-to-clean-up-former-lead-production-site-in-philly

Getting drunk on hand sanitizer

More children getting drunk on hand sanitizer
CNN
September 15, 2015
http://edition.cnn.com/2015/09/14/health/hand-sanitizer-poisoning/index.html

Six-year-old Nhaijah Russell swallowed three or four squirts of seemingly innocuous liquid hand sanitizer at school. It tasted good, she said, like strawberry.

It also contained enough alcohol to make her dangerously drunk. She arrived at the emergency room slurring her words and unable to walk.

Since 2010, poison control center hotlines across the United States have seen a nearly 400% increase in calls related to children younger than 12 ingesting hand sanitizer, according to new analysis by the Georgia Poison Center.

The amount of alcohol in hand sanitizer ranges from 45% to 95%. Ingesting even small amounts — as little as two or three squirts in some cases — can cause alcohol poisoning. By comparison, wine and beer contain about 12% and 5% alcohol

E-Cigarette Smoke: Contains Some Toxic Elements

Second-Hand E-Cigarette Smoke: Healthier Than Regular Cigarette Smoke, but Still Contains Some Toxic Elements
August 28, 2014
https://pressroom.usc.edu/second-hand-e-cigarette-smoke-healthier-than-regular-cigarette-smoke-but-still-contains-some-toxic-elements

researchers find increased levels of certain toxic metals in second-hand smoke from e-cigs

e-cigarette smoke contains the toxic element chromium, absent from traditional cigarettes, as well as nickel at levels four times higher than normal cigarettes.
In addition, several other toxic metals such as lead and zinc were also found in second-hand e-cigarette smoke

Interventions for alcohol hangover

Seeking Proof For Why We Feel Terrible After Too Many Drinks
August 18, 2014
http://www.npr.org/blogs/thesalt/2014/08/18/341360729/seeking-proof-for-why-we-feel-terrible-after-too-many-drinks

Rogers talks about the myths of hangovers — and how hangovers can be an inflammatory response, like the flu.

Clotam is a sort of – it’s like a super-powered anti-inflammatory. It’s prescribed for migraines in Europe. And in fact, it did work – that it did seem to alleviate a lot of the symptoms of hangover. Now the problem is that it’s not in the U.S. pharmacopeia.

original papers:
Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials.
BMJ. 2005 Dec 24;331(7531):1515-8.
Pittler MH, et al.
http://www.ncbi.nlm.nih.gov/pubmed/16373736
RESULTS:
Significant intergroup differences for overall symptom scores and individual symptoms were reported only for tolfenamic acid, gamma linolenic acid from B officinalis, and a yeast based preparation.
CONCLUSION:
No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover.
The most effective way to avoid the symptoms of alcohol induced hangover is to practise abstinence or moderation.

====================
Hangover headache and prostaglandins: prophylactic treatment with tolfenamic acid.
Cephalalgia. 1983 Mar;3(1):31-6.
Kaivola S, et al.
http://www.ncbi.nlm.nih.gov/pubmed/6342813
Tolfenamic acid (TA), a potent inhibitor of prostaglandin (PG) biosynthesis and action, was tested prophylactically against hangover symptoms in 30 healthy volunteers in a double-blind cross-over study. …
The plasma concentrations of PGE2 and TXB2 (a metabolite of thromboxane A2) were lower in the TA group during alcohol ingestion, while PGF2 alpha and 6-keto-PGF1 alpha (a metabolite of prostacyclin) were unaffected. TXB2 correlated with blood alcohol levels in a U-shaped manner.

Smoking is far more common among …

Smoking_by_educationAmid Smoking Decline, Look Who’s Still Lighting Up
July 31, 2014
http://www.npr.org/blogs/health/2014/07/31/336386346/amid-smoking-decline-look-whos-still-lighting-up

18.1 percent of Americans were smoking in 2012
http://www.cdc.gov/tobacco/data_statistics/fact_sheets/fast_facts

Smoking is far more common among those living below the poverty level, those with GED-level education, and among American Indian or Alaskan Natives, according to the Centers for Disease Control and Prevention.

Smoking is more lethal than it used to be

companies have re-engineered cigarettes in recent decades, increasing the toxic components of smoke.

Surgeon General Adds New Risks To Long List Of Smoking’s Harms
January 17, 2014
http://www.npr.org/blogs/health/2014/01/17/263333179/surgeon-general-report-breaks-new-ground-on-e-cigarettes

an impressive list of disorders newly deemed to be caused by smoking. They include:

  • diabetes,
  • facial deformities in babies born to smoking mothers,
  • liver and colorectal cancer,
  • age-related macular degeneration,
  • ectopic pregnancy,
  • rheumatoid arthritis and
  • erectile dysfunction

“Smoking really is even worse than we knew,” Dr. Thomas Frieden, director of the Centers for Disease Control and Prevention

Frieden says smoking is more lethal than it used to be. “Even though the Americans who smoke are smoking fewer cigarettes, the risk of dying among smokers is increasing,” he notes, quoting the new report.

companies have re-engineered cigarettes in recent decades, changing the way people inhale and increasing the toxic components of smoke.

The trend is striking. Between 1959 and 2010, the risk of lung cancer among women jumped from about three times that of those who never smoked to 26 times. Among men who smoke, the lung cancer rate more than doubled, from 12 times to 25 times the risk of never-smokers.

The CDC says changes in cigarette design and composition since the 1950s have shifted the pattern of lung cancers from a type called squamous cell carcinomas to adenocarcinomas. That’s one reason why smoking has become more deadly.

e-cigarettes … I have grave concerns that they’re doing more harm than good.”