Schizophrenia & synaptic pruning

Opening schizophrenia’s black box
Broad Institute
Jan 27, 2016

A landmark study has revealed that a person’s risk of schizophrenia is increased if they inherit specific variants in a gene related to “synaptic pruning” — the elimination of connections between neurons. The findings represent the first time that the origin of this devastating psychiatric disease has been causally linked to specific gene variants and a biological process.