Foldscope: Origami-based paper microscope
James Cybulski, James Clements, Manu Prakash
5 Mar 2014

Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes.
Merging principles of optical design with origami enables high-volume fabrication of microscopes from 2D media.
Flexure mechanisms created via folding enable a flat compact design. Structural loops in folded paper provide kinematic constraints as a means for passive self-alignment. This light, rugged instrument can survive harsh field conditions while providing a diversity of imaging capabilities, thus serving wide-ranging applications for cost-effective, portable microscopes in science and education.