Laura Bain – Living with Bipolar Type II

TEDxTerryTalks – Laura Bain – Living with Bipolar Type II
Dec 5, 2011
University of British Columbia, Vancouver, BC, Canada

Laura Bain speaks about living with Bipolar Type II Disorder, the trials and tribulations, but also how it informs her vibrant character and wonderful sense of identity.

“Laura is a very passionate person and as a 5th year Biology student she is a lover of Science. She is an avid cyclist, a teacher, an artist and a silly dancer. She is a windsurf instructor, the former vice commodore of the UBC sailing club, and a summer landscaper. She is a friend, roommate, a well-loved daughter and baby sister to three big brothers. She is also an auntie to the cutest little niece ever. Oh, there is one more thing, she is living with Bipolar Disorder.”

Tracked my mood/feelings (higher energy/lower energy; transition days) on my calendar: arrows

persistent upward arrows for about two weeks

cognitive therapy

Rebecca Jewitt. Kaitlyn Gee

“Crazy” Girl– On Surviving and Thriving with Mental Illness | Kaitlyn (Kaity) Gee | TEDxHarkerSchool
Jan 3, 2016

Kaity is a writer, a daughter, friend, etc. Among other things, she is a survivor of mental illness. Listen to her talk about her experiences, the stigma surrounding the word “mental illness,” and learning to live and rise above her disorders.

Bipolar disorder

Bipolar disorder
2010
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/psychiatry-psychology/bipolar-disorder

Bipolar disorder
http://www.drnnarang.com/bipolar_disorder.html

http://psycheducation.org/diagnosis/mixed-states/rapid-cycling-and-mixed-states-as-waves

http://psycheducation.org/diagnosis
One way to understand these states is called “mixed states”. Bipolar disorder is an unfortunate name, as it implies a North/South Pole experience. A better picture looks like this graph …
Both manic symptoms and depressive symptoms at the same time? Sure enough. Not intuitive, if you think North/South pole. But these symptoms can vary independently or occur together

2011
http://www.psychiatrictimes.com/bipolar-disorder/treatment-resistant-bipolar-disorder

Mixed states in bipolar disorder
2015
http://link.springer.com/article/10.1007%2Fs40263-015-0275-6

Manic with mixed features
> 2013
http://www.northwoodsclinic.com/page5

 

Recognition and Treatment of Bipolar Disorder in Children and Adolescents
02/28/2005
http://www.medscape.org/viewarticle/499656

08/09/2002
http://www.medscape.org/viewarticle/439472_5

2004
http://www.scielo.br/scielo.php?pid=S1516-44462004000700003&script=sci_arttext&tlng=en

2000
http://link.springer.com/chapter/10.1007%2F0-306-47521-9_3

Normal and abnormal mood states
http://www.josephbryer.com/8.html

Psychotic and nonpsychotic bipolar mixed states
1993
http://link.springer.com/article/10.1007%2FBF02191568

Pleiotropic effects on psychopathology (Lancet 2013)

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Lancet. 2013 Apr 20;381(9875):1371-9.
http://www.ncbi.nlm.nih.gov/pubmed/23453885
Cross-Disorder Group of the Psychiatric Genomics Consortium.
Erratum in: Lancet. 2013 Apr 20;381(9875):1360.

BACKGROUND:
Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories.
We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.

METHODS:
We analyzed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders

FINDINGS:
SNPs at four loci surpassed the cutoff for genome-wide significance (p<5×10(-8)) in the primary analysis: regions on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2.
Model selection analysis supported effects of these loci for several disorders.
Loci previously associated with bipolar disorder or schizophrenia had variable diagnostic specificity.
Pathway analysis supported a role for calcium channel signalling genes for all five disorders.

INTERPRETATION:
Our findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset. In particular, variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology.
These results provide evidence relevant to the goal of moving beyond descriptive syndromes in psychiatry, and towards a nosology informed by disease cause.

cited by:
Genes and the Human Condition (From Behavior to Biotechnology)
Coursera 2014
https://www.coursera.org/course/genes

DSM disorders overlap … with normality

DSM-5 “Addiction” Swallows Substance Abuse
Psychiatric Times. March 30, 2010
Allen Frances, MD
http://www.psychiatrictimes.com/addiction/dsm5-addiction-swallows-substance-abuse

All the DSM disorders overlap with one another and frequently also with normality.
For example, there is no clear boundary between bipolar and unipolar mood disorder, between anxiety and depression, even between schizophrenic and psychotic mood disorders, and so on throughout all the sections.