WHEN I was 16, I was admitted to U.C.L.A.’s neuropsychiatric institute. I’d been suffering from increasing paranoia (I thought war was imminent; I thought I would be called into battle) and lack of sleep (I paced our staircase into the early hours of morning). Most profoundly, I thought my parents were actually secret agents, …
One study led by researchers at the Yale School of Medicine found that 58 percent of people who were prescribed a psychotropic medication within the study group of roughly five million had no psychiatric diagnosis.
TEDxTerryTalks – Laura Bain – Living with Bipolar Type II
Dec 5, 2011
University of British Columbia, Vancouver, BC, Canada
Laura Bain speaks about living with Bipolar Type II Disorder, the trials and tribulations, but also how it informs her vibrant character and wonderful sense of identity.
“Laura is a very passionate person and as a 5th year Biology student she is a lover of Science. She is an avid cyclist, a teacher, an artist and a silly dancer. She is a windsurf instructor, the former vice commodore of the UBC sailing club, and a summer landscaper. She is a friend, roommate, a well-loved daughter and baby sister to three big brothers. She is also an auntie to the cutest little niece ever. Oh, there is one more thing, she is living with Bipolar Disorder.”
Tracked my mood/feelings (higher energy/lower energy; transition days) on my calendar: arrows
“Crazy” Girl– On Surviving and Thriving with Mental Illness | Kaitlyn (Kaity) Gee | TEDxHarkerSchool
Jan 3, 2016
Kaity is a writer, a daughter, friend, etc. Among other things, she is a survivor of mental illness. Listen to her talk about her experiences, the stigma surrounding the word “mental illness,” and learning to live and rise above her disorders.
One way to understand these states is called “mixed states”. Bipolar disorder is an unfortunate name, as it implies a North/South Pole experience. A better picture looks like this graph …
Both manic symptoms and depressive symptoms at the same time? Sure enough. Not intuitive, if you think North/South pole. But these symptoms can vary independently or occur together
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Lancet. 2013 Apr 20;381(9875):1371-9. http://www.ncbi.nlm.nih.gov/pubmed/23453885
Cross-Disorder Group of the Psychiatric Genomics Consortium.
Erratum in: Lancet. 2013 Apr 20;381(9875):1360.
Findings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories.
We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.
We analyzed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders
SNPs at four loci surpassed the cutoff for genome-wide significance (p<5×10(-8)) in the primary analysis: regions on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2.
Model selection analysis supported effects of these loci for several disorders.
Loci previously associated with bipolar disorder or schizophrenia had variable diagnostic specificity.
Pathway analysis supported a role for calcium channel signalling genes for all five disorders.
Our findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset. In particular, variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology.
These results provide evidence relevant to the goal of moving beyond descriptive syndromes in psychiatry, and towards a nosology informed by disease cause.