A species is considered semelparous if it is characterized by a single reproductive episode before death.

A classic example of a semelparous organism is Pacific salmon (Oncorhynchus spp.), which lives for many years in the ocean before swimming to the freshwater stream of its birth, spawning, and dying. Other semelparous animals include many insects, including some species of butterflies, cicadas, and mayflies, many arachnids, and some molluscs such as some species of squid and octopus.

CV health and cognitive aging

Ideal Cardiovascular Health and Cognitive Aging in the Northern Manhattan Study
J Am Heart Assoc. 2016
Hannah Gardener, ScD, et al.

Conclusions: The number of ideal CVH metrics was associated with less decline in the domains of Processing Speed and, to a lesser extent, of Executive Function and Episodic Memory.
Ideal CVH promotion benefits brain health and cognitive aging.

journalistic version:

Executive functions program


Your ability to reconstruct the whole …

NR2Enhancing the plasticity of the brain
Dr. Max Cynader

brain plasticity: after 20 pounds your biomechanics are different yet you still have to walk gracefully

MEMORY: your ability to reconstruct the whole from a degraded fragment



receptor, receptors


Age-Related Memory Loss & RbAp48

A Single Protein May Help Explain Memory Loss In Old Age
by Jon Hamilton
August 29, 2013
If you’re finding it harder to remember where you put the car keys, the culprit could be a brain protein with a name that’s easy to forget: RbAp48.

A shortage of this protein appears to impair our ability to remember things as we age, researchers report in the current issue of Science Translational Medicine. And boosting levels of RbAP48 in aging brains can reverse memory loss, at least in mice, they say.

The protein was studied in an area of the brain that is generally unaffected by Alzheimer’s disease.
The research “reinforces the emerging idea that Alzheimer’s disease and aging are separate entities,” says Scott Small, a neurologist at Columbia University and one of the study’s authors. It also suggests that, eventually, it should be possible to treat memory loss that’s not related to Alzheimer’s.

original article:
Molecular Mechanism for Age-Related Memory Loss: The Histone-Binding Protein RbAp48
Sci Transl Med 28 August 2013:  5 (200): 200ra115