Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults
JAMA Intern Med. Published online May 12, 2014
Richard D. Semba, MD, MPH; et al.
Importance: Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anticancer effects in humans and is related to longevity in some lower organisms.
Objective: To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans.
Design Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998 to 2009 conducted in 2 villages in the Chianti area in a population-based sample of 783 community-dwelling men and women 65 years or older.
Exposures: Twenty-four–hour urinary resveratrol metabolites.
Main Outcomes and Measures: Primary outcome measure was all-cause mortality.
Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]) and prevalent and incident cancer and cardiovascular disease.
Results: Mean (95% CI) log total urinary resveratrol metabolite concentrations were 7.08 (6.69-7.48) nmol/g of creatinine. During 9 years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4%, 31.6%, 33.5%, and 37.4%, respectively (P = .67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% CI, 0.54-1.17) compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF, prevalent or incident cardiovascular disease, or cancer.
Conclusions and Relevance: In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer or predictive of all-cause mortality.
Resveratrol levels achieved with a Western diet did not have a substantial influence on health status and mortality risk of the population in this study.
Resveratrol May Not Be The Elixir In Red Wine And Chocolate
May 13, 201410
The notion that consuming wine and chocolate, two of our favorite vices, could lead to longer, healthier lives is a tantalizing one.
Scientists first hinted at the possibility in 2006 after feeding obese mice a diet high in the compound resveratrol — which occurs naturally in grape skins, certain berries, chocolate and other plants.
They noticed that the mice lived as long as obese mice that didn’t get the compound. The ones who got the resveratrol also had fewer diseases associated with aging.
David Sinclair, with Harvard Medical School’s department of genetics, is the author of the 2006 paper in Nature … Sinclair maintains that there may be benefits to consuming high doses of the compound.
Specifically, he has shown that resveratrol hits an enzyme in the cell that activates a longevity gene, at least in animals so far.
… for mice and humans to see clinical effects, they’d have to consume 100 to 1,000 times the amount of resveratrol the Italians in the JAMA study were getting, which came mostly from wine.
And about those resveratrol supplements? “The evidence of supplements providing benefits is not conclusive,” says Richard Semba, of Johns Hopkins University’s School of Medicine, who led the study of 783 elderly adults from Tuscany’s Chianti region.
But you may as well keep drinking your favorite zinfandel, merlot or Sangiovese.
Moderate alcohol consumption may prevent bone loss in older women.
And Semba tells The Salt there are more than three dozen polyphenols besides resveratrol in red wine that could be beneficial.
“These polyphenols might be working in concert with each other,” …
You can also hold on to the chocolate: There’s still pretty strong evidence that it may be good for the heart and waistline.
We can thank our gut microbes for that.