Denis Raymond

Glioblastoma Multiforme – Denis’ Story
OttawaCancer
Oct 27, 2014

Update: (1 year ago) I am over two years since initial diagnosis, and I am doing very well… MRIs continue to show stability. I have all the energy I had pre-surgery, and then some. … the use of this device IN CONJUNCTION WITH temozolomide (the prescribed chemotherapy). It has shown to help primarily when it is in combination with another treatment.
http://www.optune.com
https://www.youtube.com/user/Optuneus

Mother fights brain cancer with electric fields
Reuters
Jun 2, 2015

http://www.npr.org/sections/health-shots/2017/07/20/538295015/john-mccain-was-diagnosed-with-a-glioblastoma-among-the-deadliest-of-cancers

Cancer patients’s survival time & insurance status

Influence of insurance status on survival of adults with glioblastoma multiforme: A population-based study
Xiaoming Rong MD, et al.
Cancer. 8 August 2016
http://onlinelibrary.wiley.com/doi/10.1002/cncr.30160/full

Insurance status and disparities in disease presentation, treatment, and outcomes for men with germ cell tumors
Sarah C. Markt ScD, et al.
Cancer. 8 August 2016
http://onlinelibrary.wiley.com/doi/10.1002/cncr.30159/full

The Toxins of William B. Coley

Training The Immune System To Fight Cancer Has 19th-Century Roots
December 28, 2015
http://www.npr.org/sections/health-shots/2015/12/28/459218765/cutting-edge-cancer-treatment-has-its-roots-in-19th-century-medicine

A novel immunotherapy drug is credited for successfully treating former President Jimmy Carter’s advanced melanoma. Instead of killing cancer cells, these drugs boost the patient’s immune system, which does the job instead.

Immunotherapy is cutting-edge cancer treatment, but the idea dates back more than 100 years, to a young surgeon who was willing to think outside the box.

related:
The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas
Edward F McCarthy, MD
Iowa Orthop J. 2006; 26: 154–158.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888599

NFL Player Beats Cancer

NFL Player Beats Cancer, Returns To The Field
September 17, 2015
http://hereandnow.wbur.org/2015/09/17/nfl-eric-berry-cancer

Kansas City Chiefs safety Eric Berry played his first regular season NFL game last weekend, just 10 months after he was diagnosed with Hodgkin’s lymphoma.

Other professional athletes, such as hockey player Mario Lemieux and baseball player Jon Lester, have also recovered from lymphoma and resumed their careers.

Melanoma: Explosion Of New Cancer Treatments

Explosion Of New Cancer Treatments Presents A ‘Very Exciting Time’
August 20, 2015
http://www.npr.org/2015/08/20/433257633/explosion-of-new-cancer-treatments-presents-a-very-exciting-time

with melanoma ’cause about five years ago, I would’ve said he has a prognosis of somewhere between six months to a year. But over the last five years, the treatments in melanoma have just exploded with really, really exciting new treatments that have changed that to a point that we actually don’t have a good estimate yet in terms of long-term prognosis will be.

Trying A Skin Cancer Drug To Treat A Brain Tumor

Why Doctors Are Trying A Skin Cancer Drug To Treat A Brain Tumor
March 26, 2015
http://www.npr.org/blogs/health/2015/03/26/394327128/why-doctors-are-trying-a-skin-cancer-drug-to-treat-a-brain-tumor

Anselmo’s tumor had a BRAF mutation common in skin cancer, but very unusual for a brain tumor.

Her oncologist, David Hyman at Memorial Sloan Kettering, enrolled Anselmo into a new kind of drug trial. Called a basket trial, the study is designed to include people whose tumors have the same kind of genetic fingerprint regardless of where in the body the tumors are found.

Today, Anselmo is doing well. She’s been in the clinical trial for a year now, and continues to take Zelboraf (or vemurafenib generically) daily. The pills have kept her cancer from growing.

There are side effects, of course. She’s lost some peripheral vision, though she’s been able to compensate. And Zelboraf is expensive

After all the misfortunes she’s been through, it would be easy to think Anselmo has been incredibly unlucky. But she doesn’t see it that way. No, she says after rehearsing for her comeback show, “I’m the luckiest.”

Carcinogen In Colas Has FDA Reviewing Data

Potential Carcinogen In Colas Has FDA Reviewing Data
January 23, 2014
http://www.npr.org/blogs/thesalt/2014/01/23/265245172/potential-carcinogen-in-colas-has-fda-reviewing-data

A new study from Consumer Reports finds varying levels of a chemical compound classified as a possible human carcinogen in many popular brands of soda.

The findings have prompted the Food and Drug Administration to take a new look at the compound, 4-methylimidazole — or 4-MEI for short. It is found in the caramel color that soda makers use to dye the drinks brown.

Under California’s Prop 65, the chemical is included on a state list of substances that can cause cancer. An arm of the World Health Organization has classified 4-MEI as a possible carcinogen.

Testing by Consumer Reports found very low levels of 4-MEI in Coca-Cola, Coke Zero and Diet Coke.
As we’ve reported, 4-MEI was greatly reduced in Coke products after Coke worked with its supplier to reformulate the caramel manufacturing process.

But the study did find higher levels of the compound in some Pepsi products, particularly in Pepsi One. During an eight-month period, the researchers purchased a dozen 12-ounce servings of Pepsi One from different batches at stores in California.

The more you know, the less you want to know

How A Co-Worker’s Breast Cancer Diagnosis Affects Colleagues
by Shankar Vedantam
August 13, 2014
http://www.npr.org/2014/08/13/340005026/how-a-co-worker-s-breast-cancer-diagnosis-affects-colleagues

When a woman at work experiences breast cancer, does that make her colleagues more likely to get mammograms and be proactive about their own health?

psychologists and social scientists talk about this idea of information aversion – the idea that maybe you don’t want to find out about some really bad news because of the way it makes you feel.

INSKEEP: The more you know, the less you want to know.

Red meat consumption and mortality

Red meat consumption and mortality: results from 2 prospective cohort studies.
Arch Intern Med. 2012 Apr 9;172(7):555-63.
Pan A, et al.
http://www.ncbi.nlm.nih.gov/pubmed/22412075

BACKGROUND:
Red meat consumption has been associated with an increased risk of chronic diseases. However, its relationship with mortality remains uncertain.

METHODS:
We prospectively observed 37 698 men from the Health Professionals Follow-up Study (1986-2008) and 83 644 women from the Nurses’ Health Study (1980-2008) who were free of cardiovascular disease (CVD) and cancer at baseline. Diet was assessed by validated food frequency questionnaires and updated every 4 years.

RESULTS:
We documented 23 926 deaths (including 5910 CVD and 9464 cancer deaths) during 2.96 million person-years of follow-up. After multivariate adjustment for major lifestyle and dietary risk factors, the pooled hazard ratio (HR) (95% CI) of total mortality for a 1-serving-per-day increase was 1.13 (1.07-1.20) for unprocessed red meat and 1.20 (1.15-1.24) for processed red meat. The corresponding HRs (95% CIs) were 1.18 (1.13-1.23) and 1.21 (1.13-1.31) for CVD mortality and 1.10 (1.06-1.14) and 1.16 (1.09-1.23) for cancer mortality.
We estimated that substitutions of 1 serving per day of other foods (including fish, poultry, nuts, legumes, low-fat dairy, and whole grains) for 1 serving per day of red meat were associated with a 7% to 19% lower mortality risk. We also estimated that 9.3% of deaths in men and 7.6% in women in these cohorts could be prevented at the end of follow-up if all the individuals consumed fewer than 0.5 servings per day (approximately 42 g/d) of red meat.

CONCLUSIONS:
Red meat consumption is associated with an increased risk of total, CVD, and cancer mortality.
Substitution of other healthy protein sources for red meat is associated with a lower mortality risk.

Comment in:
Additional ways to diminish the deleterious effects of red meat. [Arch Intern Med. 2012]

Higher red meat consumption is associated with increased risk of all-cause, cardiovascular, and cancer mortality. [Evid Based Nurs. 2012]

Holy Cow! What’s good for you is good for our planet: comment on “Red Meat Consumption and Mortality”. [Arch Intern Med. 2012]

journalistic version:
Death By Bacon? Study Finds Eating Meat Is Risky
March 12, 2012
http://www.npr.org/blogs/thesalt/2012/03/12/148457233/death-by-bacon-study-finds-eating-meat-is-risky