Transgenerational effects

Transgenerational effects

Vinclozolin has been demonstrated to have trangenerational effects, meaning that not only is the initial animal affected, but effects are also seen in subsequent generations.
One study demonstrated that vinclozolin impaired male fertility not only in the first generation that was exposed in utero, but in males born for three generations and beyond.[1] …
After three generations, male offspring continued to show low sperm count, prostate disease and high rates of testicular cell apoptosis.[1][2]

It has been reported that these transgenerational reports correlate with epigenetic changes, specifically, an alteration in DNA methylation in the male germ line.[3]

[1] Gilbert, Scott; Epel, David (2009). Ecological Developmental Biology [Integrating Epigenetics, Medicine, and Evolution]. MA: Sinauer Associates. p. 231. ISBN 978-0-87893-299-3.

[2] “Epigenetic Transgenerational Actions of Vinclozolin on the Development of Disease and Cancer”. Critical Reviews in Oncogenesis.

[3] “Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome”.