Total Synthesis of a Functional Designer Eukaryotic Chromosome
Science. 27 March 2014
Rapid advances in DNA synthesis techniques have made it possible to engineer viruses, biochemical pathways and assemble bacterial genomes. Here, we report the synthesis of a functional 272,871–base pair designer eukaryotic chromosome, synIII, which is based on the 316,617–base pair native Saccharomyces cerevisiae chromosome III.
Changes to synIII include TAG/TAA stop-codon replacements, deletion of subtelomeric regions, introns, transfer RNAs, transposons, and silent mating loci as well as insertion of loxPsym sites to enable genome scrambling.
SynIII is functional in S. cerevisiae. Scrambling of the chromosome in a heterozygous diploid reveals a large increase in a-mater derivatives resulting from loss of the MATα allele on synIII.
The complete design and synthesis of synIII establishes S. cerevisiae as the basis for designer eukaryotic genome biology.
Scientists Move Closer to Inventing Artificial Life
Synthetic biology advances with a man-made chromosome inserted into live brewer’s yeast.
National Geographic. March 27, 2014
Student Assembly Drives Yeast Project
Science 28 March 2014: 343(6178):1429
Building the Ultimate Yeast Genome
Science 28 March 2014: 1426-1429.
The Science of Genius
Outstanding creativity in all domains may stem from shared attributes and a common process of discovery
Scientific American Mind. Special Edition: Creativity
Winter 2014. pp. 20-27
By Dean Keith Simonton
Does Genius Follow The Ten-Year Rule?
Psychology Today. February 1, 2011
The Art of Medicine: Perspiration, inspiration, and the 10-year rule
thelancet.com Vol 376 October 30, 2010
the 10-year rule was first identified by psychologist John Hayes in 1989
Science and Fiction – A Springer Series
Readers can look forward to a broad range of topics, as intriguing as they are important. Here just a few by way of illustration:
• Time travel, superluminal travel, wormholes, teleportation
• Extraterrestrial intelligence and alien civilizations
• Artificial intelligence, planetary brains, the universe as a computer, simulated worlds
• Non-anthropocentric viewpoints
• Synthetic biology, genetic engineering, developing nanotechnologies
• Eco/infrastructure/meteorite-impact disaster scenarios
• Future scenarios, transhumanism, posthumanism, intelligence explosion
• Virtual worlds, cyberspace dramas
• Consciousness and mind manipulation
7 Billion People And Trillions Of Creatures To Be Photographed Together On July 19
by Robert Krulwich
June 27, 2013
Carl Sagan thought, how small we look, how small we are — which inspired him to write his eloquent Pale Blue Dot meditation, which, if you haven’t read it lately, take a minute and a half to look at this short version … Carl Sagan himself is narrating.
Pale Blue Dot: A Vision of the Human Future in Space
by Carl Sagan
Ballantine Books; Reprint edition (September 8, 1997)
Juno probe captures movie of Earth-Moon ‘dance’
10 December 2013
Earth from the International Space Station
June 12, 2103
A view of Earth from the Cupola on the earth-facing side of the International Space Station is seen in this NASA handout photo taken June 12, 2103.
Visible in the top left foreground is a Russian Soyuz crew capsule.
In the lower right corner, a solar array panel can be seen.
This Building Is Supergreen. Will It Be Copied?
April 22, 2013
It’s a project of the environmentally progressive Bullitt Foundation.