De novo mutations: 74 SNVs per genome

Current estimates of the average mutation frequencies for the different types of de novo genomic variation observed per generation per genome.

De novo mutations in human genetic disease
Nature Reviews Genetics 13, 565-575 (August 2012)
Joris A. Veltman, et al.

New mutations have long been known to cause genetic disease, but their true contribution to the disease burden can only now be determined using family-based whole-genome or whole-exome sequencing approaches.

In this Review we discuss recent findings suggesting that de novo mutations play a prominent part in rare and common forms of neurodevelopmental diseases, including intellectual disability, autism and schizophrenia.
De novo mutations provide a mechanism by which early-onset reproductively lethal diseases remain frequent in the population.
These mutations, although individually rare, may capture a significant part of the heritability for complex genetic diseases that is not detectable by genome-wide association studies.