Environmental epigenomics and disease susceptibility
Randy L. Jirtle and Michael K. Skinner
Nature Reviews Genetics 8, 253-262 (April 2007)
Alterations in methylation status during development.
During embryonic development and gonadal sex determination, primordial germ cells undergo genome-wide demethylation, which erases previous parental-specific methylation marks that regulate imprinted gene expression.