Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding
Cell. Volume 156, Issue 3, p495–509, 30 January 2014
•Maternal HFD feeding during lactation impairs metabolic health of the offspring
•Maternal HFD during lactation impairs formation of melanocortin projections
•Abnormal insulin action in POMC neurons impairs POMC projections to preautonomic PVH
•Abrogating POMC insulin action improves glucose metabolism despite maternal HFD
Can Mom’s Pregnancy Diet Rewire Baby’s Brain For Obesity?
January 24, 2014