Environmental epigenomics and disease susceptibility

Alterations in methylation status during development.

Environmental epigenomics and disease susceptibility
Randy L. Jirtle and Michael K. Skinner
Nature Reviews Genetics 8, 253-262 (April 2007)
http://www.nature.com/nrg/journal/v8/n4/fig_tab/nrg2045_ft.html

Alterations in methylation status during development.

During embryonic development and gonadal sex determination, primordial germ cells undergo genome-wide demethylation, which erases previous parental-specific methylation marks that regulate imprinted gene expression.