The Depression Connection

EEG data reveal how tightly connected the frontal cortex (red) is to the rest of the brain in depression (left) and health (right).

The Depression Connection
Scientific American Mind 23, 9 (2012)

Brain regions may communicate excessively in depression

Like an overwhelmed traffic cop, the depressed brain may transmit signals among regions in a dysfunctional way.
Recent brain-imaging studies suggest that areas of the brain involved in mood, concentration and conscious thought are hyperconnected, which scientists believe could lead to the problems with focus, anxiety and memory frequently seen in depression.

hyperconnectivity is a hallmark of depression in the brain