Chemical ‘clock’ tracks ageing more precisely than ever before
DNA methylation could shed light on why some tissues are prone to cancer.
Nature. 21 October 2013
In a paper published today in Genome Biology, Horvath reveals how methylation levels change in human tissues from before birth to the age of 101, and shows that it is a near-perfect predictor of age for non-cancerous tissues.
The study “represents the most convincing demonstration so far” of age-associated changes in DNA methylation that are consistent across most tissue types, says Andrew Teschendorff, a computational biologist at University College London.
DNA methylation age of human tissues and cell types
Genome Biology 2013, 14(10):R115
Conclusions: I propose that DNA methylation age measures the cumulative effect of an epigenetic maintenance system. This novel epigenetic clock can be used to address a host of questions in developmental biology, cancer and aging research.
ScienceClub: Oct. 29, 2013