Scientists Urge Temporary Moratorium On Human Genome Edits

Scientists Urge Temporary Moratorium On Human Genome Edits
March 20, 2015
http://www.npr.org/blogs/health/2015/03/20/394311141/scientists-urge-temporary-moratorium-on-human-genome-edits

A new technology called CRISPR could allow scientists to alter the human genetic code for generations. That’s causing some leading biologists and bioethicists to sound an alarm. They’re calling for a worldwide moratorium on any attempts to alter the code, at least until there’s been time for far more research and discussion.

The big worry is that CRISPR and other techniques will be used to perform germline genetic modification.

Another concern is that this could open the door to what people call designer babies.

see also:
https://franzcalvo.wordpress.com/2015/03/19/scientists-sound-alarm-over-dna-editing-of-human-embryos

http://www.npr.org/sections/health-shots/2016/06/02/480466940/scientists-say-they-hope-to-create-a-human-genome-in-the-lab

CRISPR gene editing produces unwanted DNA deletions
DNA-cutting enzyme used for genetic modification can create large deletions and shuffle genes.
16 July 2018
https://www.nature.com/articles/d41586-018-05736-3

A CRISPR Way To Fix Faulty Genes

A CRISPR Way To Fix Faulty Genes
by Joe Palca
June 26, 2014
http://www.npr.org/blogs/health/2014/06/26/325213397/a-crispr-way-to-fix-faulty-genes

“It’s really powerful, it’s a really exciting development,” says Craig Mello of the University of Massachusetts Medical School.
He won the Nobel Prize in 2006 for a different technique that also lets scientists modify how genes work.
But, Mello says, this new genetic tool – known as CRISPR for clustered regularly interspersed short palindromic repeats — is more powerful, “because now you can essentially change a genome at will to almost anything you want. The sky’s the limit.”

therapies for people with genetic blood diseases like sickle cell disease and thalassemia.

original paper:
CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology  32, 347–355 (2014)
Jeffry D Sander & J Keith Joung
http://www.nature.com/nbt/journal/v32/n4/full/nbt.2842.html

related:
Americans Win Nobel for Work in Genetic Therapy
October 02, 2006
http://www.npr.org/templates/story/story.php?storyId=6179998

http://www.nature.com/news/crispr-the-disruptor-1.17673