The Wrong Pill Can Play With Your Mind

The Wrong Pill Can Play With Your Mind
By JAIME LOWESEPT. 30, 2017
https://www.nytimes.com/2017/09/30/opinion/sunday/bipolar-medication-depakote-lithium-.html

WHEN I was 16, I was admitted to U.C.L.A.’s neuropsychiatric institute. I’d been suffering from increasing paranoia (I thought war was imminent; I thought I would be called into battle) and lack of sleep (I paced our staircase into the early hours of morning). Most profoundly, I thought my parents were actually secret agents, …

lithium
Tegretol

Depakote D.R. (for delayed release)
Depakote E.R. (for extended release).

One study led by researchers at the Yale School of Medicine found that 58 percent of people who were prescribed a psychotropic medication within the study group of roughly five million had no psychiatric diagnosis.

medication education

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Smart Drugs (Nature. Mar 2016)

Smart drugs: A dose of intelligence.
Nature. 2016 Mar 3;531(7592):S2-3.
Dance A.
https://www.ncbi.nlm.nih.gov/pubmed/26934523
http://www.nature.com/nature/journal/v531/n7592_supp/full/531S2a.html

Adderall (amphetamine) and Ritalin (methylphenidate) — treatments for attention-deficit hyperactivity disorder (ADHD)
modafinil, which is a medication for sleep disorders such as narcolepsy.

it is not clear whether the same medications can push a neurologically healthy, well-rested individual onto a higher cognitive plane.

“By far the most commonly used neurocognitive enhancers are nicotine and caffeine,” says Peter Morgan, a psychiatrist at Yale University School of Medicine in New Haven, Connecticut.

https://franzcalvo.wordpress.com/2017/03/18/ravens-progressive-matrices

many cognitive tests had been designed to assess impairment, not enhancement. For example, people with a brain injury or dementia may struggle with a clock-drawing test, but someone with normal cognition will usually get it right — leaving no room for smart drugs to assist.

regular use of coffee and cigarettes causes consumers’ brains to adapt so that they need the stimulant just to function at their normal cognitive level.

https://franzcalvo.wordpress.com/2017/03/18/extreme-perseverance

ethical questions. One such concern revolves around social equality. Not everyone has equal access to smart drugs,…

they stick to coffee, tea or energy drinks. Morgan, for his part, suggested that the same cognitive benefits can be achieved by simply taking a refreshing nap.

related:
Can You Make Yourself Smarter?
The RSA, 2014


nicotine patch

Allyl isothiocyanate

https://en.wikipedia.org/wiki/Allyl_isothiocyanate
Allyl isothiocyanate is the organosulfur compound with the formula CH2CHCH2NCS. It is responsible for the pungent taste of mustard, radish, horseradish, and wasabi. This pungency and the lachrymatory effect of AITC is mediated through the TRPA1 and TRPV1 ion channels.

It is slightly soluble in water, but more soluble in most organic solvents.

Oncology
Based on in vitro experiments and animal models, allyl isothiocyanate exhibits many desirable attributes of a cancer chemopreventive agent.

carriers

proteinaceous carriers
http://www.nature.com/nrd/journal/v7/n3/fig_tab/nrd2438_F1.html

The carrier protein from protein–polysaccharide conjugate vaccines is processed by the polysaccharide-specific B cell …
http://www.nature.com/nri/journal/v9/n3/fig_tab/nri2494_F1.html

 

carriersSmith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition
H. John Smith, Hywel Williams
CRC Press, Oct 10, 2005
p. 52

Biobrane, a membrane carrier made of a silicone membrane with an integrated woven nylon mesh.
http://www.nature.com/mt/journal/v10/n1/fig_tab/mt20041201f4.html

David Casarett, MD

When Weed Is The Cure: A Doctor’s Case for Medical Marijuana  
July 14, 2015
http://www.npr.org/sections/health-shots/2015/07/14/422876973/when-weed-is-the-cure-a-doctors-case-for-medical-marijuana

Dr. David Casarett, is the director of hospice and palliative care at the University of Pennsylvania Perelman School of Medicine.

I found it though, at least for me, at the cost of most of the most common side effects of acute use of medical marijuana — confusion, hallucinations. I think — mostly because the dose I gave myself, being relatively unfamiliar with marijuana and very unfamiliar with the strength of what I managed to obtain — [I] was really blindsided by some of the acute side effects like confusion and hallucinations, which I honestly should have expected, but didn’t. …

[I heard] air traffic controllers vectoring flights into and out of the Phoenix airport — those voices were coming from my living room, where there really weren’t any air traffic controllers.

CASARETT: The acute cognitive side effects, meaning what we all experience in the first two to six hours after being exposed to medical marijuana, are fairly well-described.
They tend to be fairly short-term. They tend to be predictable.
As long as you know what the dose is that you’re getting.
I think what makes me a little bit nervous, and something that we don’t quite understand from the research that’s been done yet, but there’s been enough research done to make many of us worry that long-term cognitive effects for somebody who smokes half a joint a day for 10, 20, 30 years, there have been several studies now that have found some combination of a decrease in neuropsychological function, often decreases or changes in thinking and memory, also changes in brain structure, decreases in the volume of certain areas of the brain, like the cortex or the amygdala, that are associated with thinking and memory.