That Drug Expiration Date May Be More Myth Than Fact

That Drug Expiration Date May Be More Myth Than Fact
July 18, 2017
https://www.npr.org/sections/health-shots/2017/07/18/537257884/that-drug-expiration-date-may-be-more-myth-than-fact

The box of prescription drugs had been forgotten in a back closet of a retail pharmacy for so long that some of the pills predated the 1969 moon landing. Most were 30 to 40 years past their expiration dates …

A dozen of the 14 compounds were still as potent as they were when they were manufactured, some at almost 100 percent of their labeled concentrations.

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chemical restraint

Old And Overmedicated: The Real Drug Problem In Nursing Homes
December 8, 2014
https://www.npr.org/sections/health-shots/2014/12/08/368524824/old-and-overmedicated-the-real-drug-problem-in-nursing-homes

Federal law prohibits the use of antipsychotics and other psychoactive drugs for the convenience of staff. It’s called a “chemical restraint.” There has to be a documented medical need for the drugs.

The Wrong Pill Can Play With Your Mind

The Wrong Pill Can Play With Your Mind
By JAIME LOWESEPT. 30, 2017
https://www.nytimes.com/2017/09/30/opinion/sunday/bipolar-medication-depakote-lithium-.html

WHEN I was 16, I was admitted to U.C.L.A.’s neuropsychiatric institute. I’d been suffering from increasing paranoia (I thought war was imminent; I thought I would be called into battle) and lack of sleep (I paced our staircase into the early hours of morning). Most profoundly, I thought my parents were actually secret agents, …

lithium
Tegretol

Depakote D.R. (for delayed release)
Depakote E.R. (for extended release).

One study led by researchers at the Yale School of Medicine found that 58 percent of people who were prescribed a psychotropic medication within the study group of roughly five million had no psychiatric diagnosis.

medication education

Smart Drugs (Nature. Mar 2016)

Smart drugs: A dose of intelligence.
Nature. 2016 Mar 3;531(7592):S2-3.
Dance A.
https://www.ncbi.nlm.nih.gov/pubmed/26934523
http://www.nature.com/nature/journal/v531/n7592_supp/full/531S2a.html

Adderall (amphetamine) and Ritalin (methylphenidate) — treatments for attention-deficit hyperactivity disorder (ADHD)
modafinil, which is a medication for sleep disorders such as narcolepsy.

it is not clear whether the same medications can push a neurologically healthy, well-rested individual onto a higher cognitive plane.

“By far the most commonly used neurocognitive enhancers are nicotine and caffeine,” says Peter Morgan, a psychiatrist at Yale University School of Medicine in New Haven, Connecticut.

https://franzcalvo.wordpress.com/2017/03/18/ravens-progressive-matrices

many cognitive tests had been designed to assess impairment, not enhancement. For example, people with a brain injury or dementia may struggle with a clock-drawing test, but someone with normal cognition will usually get it right — leaving no room for smart drugs to assist.

regular use of coffee and cigarettes causes consumers’ brains to adapt so that they need the stimulant just to function at their normal cognitive level.

https://franzcalvo.wordpress.com/2017/03/18/extreme-perseverance

ethical questions. One such concern revolves around social equality. Not everyone has equal access to smart drugs,…

they stick to coffee, tea or energy drinks. Morgan, for his part, suggested that the same cognitive benefits can be achieved by simply taking a refreshing nap.

related:
Can You Make Yourself Smarter?
The RSA, 2014


nicotine patch

Allyl isothiocyanate

https://en.wikipedia.org/wiki/Allyl_isothiocyanate
Allyl isothiocyanate is the organosulfur compound with the formula CH2CHCH2NCS. It is responsible for the pungent taste of mustard, radish, horseradish, and wasabi. This pungency and the lachrymatory effect of AITC is mediated through the TRPA1 and TRPV1 ion channels.

It is slightly soluble in water, but more soluble in most organic solvents.

Oncology
Based on in vitro experiments and animal models, allyl isothiocyanate exhibits many desirable attributes of a cancer chemopreventive agent.