Scottish Nurse Who Recovered From Ebola is Back …

Scottish Nurse Who Recovered From Ebola Is Back In Isolation
October 09, 2015
http://www.npr.org/sections/goatsandsoda/2015/10/09/447211121/scottish-nurse-who-recovered-from-ebola-is-back-in-isolation

Mehta at Emory says the virus is capable of lingering in some patients long after they’ve recovered. The two main reservoirs are the testicles and the eyes. But his team has only seen this happen in men.

There are roughly 17,000 survivors in the region. Liberia has already had at least one case of a male survivor who still carried Ebola in his semen and sexually transmitted the virus to a woman, who later died.
That new case occurred six months after the original patient had been declared Ebola-free.

related:
https://en.wikipedia.org/wiki/Immune_privilege

https://franzcalvo.wordpress.com/2016/03/09/zika

Ebola: 260 health workers infected, 134 dead

Ebola Outbreak Takes Toll On Africa’s Health Workers
September 01, 2014
http://www.npr.org/2014/09/01/345044302/ebola-outbreak-takes-toll-on-africas-health-workers

Nearly 260 health workers in West Africa have been infected, and 134 have died. Dr. Robert Garry of Tulane University, who worked with five who died, discusses the devastation in the community.

ZMapp reverses Ebola virus disease

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Xiangguo Qiu, et al.
Nature. 29 August 2014
http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature13777.html

Without an approved vaccine or treatment, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission.
These approaches, however, have yet to end the 2014 outbreak of Ebola after its prolonged presence in West Africa.
Here we show that a combination of monoclonal antibodies (ZMapp), optimized from two previous antibody cocktails, is able to rescue 100% of rhesus macaques when treatment is initiated up to 5 days post-challenge.
High fever, viraemia and abnormalities in blood count and blood chemistry were evident in many animals before ZMapp intervention. Advanced disease, as indicated by elevated liver enzymes, mucosal haemorrhages and generalized petechia could be reversed, leading to full recovery. ELISA and neutralizing antibody assays indicate that ZMapp is cross-reactive with the Guinean variant of Ebola. ZMapp exceeds the efficacy of any other therapeutics described so far, and results warrant further development of this cocktail for clinical use.

Medical research: Ebola therapy protects severely ill monkeys
Thomas W. Geisbert
Nature (29 August 2014)
http://www.nature.com/nature/journal/vnfv/ncurrent/full/nature13746.html
A blend of three monoclonal antibodies has completely protected monkeys against a lethal dose of Ebola virus. Unlike other post-infection therapies, the treatment works even at advanced stages of the disease.

journalistic version:
http://www.npr.org/blogs/health/2014/08/29/344228124/experimental-drug-zmapp-saves-monkeys-stricken-with-ebola

Peter Piot Never Imagined An Outbreak Like This

The Co-Discoverer Of Ebola Never Imagined An Outbreak Like This
August 29, 2014
http://www.npr.org/blogs/goatsandsoda/2014/08/29/344257046/the-co-discoverer-of-ebola-never-imagined-an-outbreak-like-this

As a young scientist in Belgium, Peter Piot was part of a team that discovered the Ebola virus in 1976.

He took his first trip to Africa to investigate this mysterious disease.
In the Democratic Republic of Congo, he met people who had contracted it. “I’ll never forget the glazed eyes, the staring and the pain … this type of expression in the eyes … telling me I’m going to die,” says Piot. “That I’ll never forget.”

Piot went on to study AIDS in the 1980s and became founding executive director of the Joint United Nations Program on HIV/AIDS.
He is now director of the London School of Hygiene and Tropical Medicine.

A Virtual Outbreak Offers Hints Of Ebola’s Future

A Virtual Outbreak Offers Hints Of Ebola’s Future
August 14, 2014
http://www.npr.org/blogs/health/2014/08/14/340346575/a-virtual-outbreak-offers-hints-of-ebolas-future

“I’ve spent a lot of time doing computer models of disease transmission, but rarely does it involve something in Africa. Africa is often overlooked,” says Bryan Lewis, a computational epidemiologist at Virginia Tech.

“Some of those factors are the ones that are hard to measure,” he says. “You’ve got to choose how much of this complexity you care to explicitly represent.”

“At the moment, these models — at least for Sierra Leone and Liberia — we aren’t putting in any mitigating factors.

Given that all this modeling is as much an art as a science, different groups working on the problem have been comparing notes. They’ve also been fielding calls from government officials and policymakers.

Martin Meltzer, who heads up the unit at the Centers for Disease Control and Prevention that’s been creating computer models of the outbreak, says that people always ask him the same two questions: “How many people are going to die, and when is this going to end?

Fruit bats just carry the Ebola virus

The Sources And Symptoms Of A Disease With A Global Reputation
March 25, 2014
http://www.npr.org/2014/03/25/294385226/the-sources-and-symptoms-of-a-disease-with-a-global-reputation

SIEGEL: How do people typically contract Ebola?

ROLLIN: More likely from an animal that had been infected. It could be the reservoir. And for Ebola, the reservoir will be a fruit bat.
The bat will suck and excrete the virus, maybe a bite or it could be also in the blood of the bat and when people kill them during the hunting or they could be in contact with that blood or urine or feces.

SIEGEL: And the bat, the carrier, the reservoir, you would say, survives.

ROLLIN: Yeah. They just carry the virus and seems to be in good health.

related:
http://www.npr.org/blogs/health/2014/04/11/301418627/ebola-drug-could-be-ready-for-human-testing-next-year