Cathepsin B ties exercise to memory

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function
Cell Metabolism. 2016. In press.
Hyo Youl Moon, et al.
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30247-9
Highlights:

  • Proteomics of AICAR-treated L6 muscle cells reveals myokine cathepsin B (CTSB)
  • Exercise increases CTSB levels in mouse, monkey, and human plasma
  • Running does not improve memory or adult neurogenesis in CTSB knockout mice
  • CTSB enhances neurotrophin levels in adult hippocampal progenitor cells
  • In humans, plasma CTSB levels are positively correlated with fitness and memory

journalistic version:
A Protein That Moves From Muscle To Brain May Tie Exercise To Memory
June 23, 2016
http://www.npr.org/sections/health-shots/2016/06/23/483245084/a-protein-that-moves-from-muscle-to-brain-may-tie-exercise-to-memory

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