Helminth infection promotes colonization resistance via type 2 immunity
Science 29 Apr 2016: Vol. 352, Issue 6285, pp. 608-612
Parasitic worms affect gut microbes
Improved hygiene practices in high-income countries may come with an increased risk of developing inflammatory bowel disease (IBD) or other similar disorders. Ramanan et al. show that intestinal helminth infection, caused by parasitic worms, protects IBD-susceptible mice from developing the disease.
The infection increases specific protective species and limits other inflammatory members of the microbiota.
People from helminth-endemic regions harbored a similar protective microbiota, and their deworming led to an increase in inflammatory Bacteroidales species, similar to what the authors observed in the mice. Thus, a changing microbial environment may shape susceptibility to inflammatory disease.
When Parasites Could Be The Treatment Instead Of The Illness
April 14, 2016