Orbitofrontal cortex and decision-making

Cross-species studies of orbitofrontal cortex and value-based decision-making
Jonathan D Wallis
Nature Neuroscience  15, 13–19 (2012)
http://www.nature.com/neuro/journal/v15/n1/full/nn.2956.html

Recent work has emphasized the role that orbitofrontal cortex (OFC) has in value-based decision-making.

However, it is also clear that a number of discrepancies have arisen when comparing the findings from animal models to those from humans. Here, we examine several possibilities that might explain these discrepancies, including anatomical difference between species, the behavioral tasks used to probe decision-making and the methodologies used to assess neural function.
Understanding how these differences affect the interpretation of experimental results will help us to better integrate future results from animal models.
This will enable us to fully realize the benefits of using multiple approaches to understand OFC function.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s