Prognosis in autoimmune and infectious disease: new insights from genetics
Clinical & Translational Immunology (2014) 3, e15
James C Lee, et al.
Keywords: autoimmunity; FOXO3; genetics; infection; prognosis
despite the apparent success, GWAS results have only explained a relatively small proportion of the total heritability of each disease.
Work is now underway to try to identify the ‘missing heritability’ through a variety of complementary methods, including:
- whole-genome sequencing (to identify rare variants that may have larger effect sizes) and
- studies to examine interactions between a given gene and other genes (epistasis) and
- between genes and the environment.