Schizotypy & COMT high activity allele

Higher scores of self reported schizotypy in healthy young males carrying the COMT high activity allele
Molecular Psychiatry, 2002, Volume 7, Number 7, Pages 706-711
D Avramopoulos, et al.
http://www.nature.com/mp/journal/v7/n7/full/4001070a.html

Schizotypal personality often precedes the development of schizophrenia and it is considered by some to be a low end of the schizophrenia spectrum.
It has also been found to be present in high frequency in schizophrenics’ relatives (reviewed by Webb et al), suggesting a common genetic background with the disease.
Although many studies have shown aggregation of schizotypal personality in schizophrenics’ families, when positive or negative symptoms are examined there is lack of consistency in the findings.
Nevertheless there have been reports of significant heritability for schizotypal personality and it has been suggested that positive and negative symptoms in schizophrenia correlate with the corresponding symptoms in schizotypal relatives.
It therefore seems likely, that schizotypal personality represents a condition attributable to some (but possibly not all) of the genes that predispose to schizophrenia, as it is a common but not a consistent premorbid finding.

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