Heavy Metal Poisoning.
Hu H. Chapter e49.
In: Harrison’s Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012.
Aluminum contributes to the enceph alopathy in patients with severe renal disease, who are undergoing dialysis (Chap. 353).
High levels of aluminum are found in the neurofibrillary tangles in the cerebral cortex and hippocampus of patients with Alzheimer’s disease, as well as in the drinking water and soil of areas with an unusually high incidence of Alzheimer’s.
The experimental and epidemiologic evidence for the aluminum–Alzheimer’s disease link remains relatively weak, however, and it cannot be concluded that aluminum is a causal agent or a contributing factor in neurodegenerative disease.